Dittami, James P.
Abbott Bioresearch Center
Antibody Drug Conjugates (ADCs) represent a rapidly growing and extensively potent class of pharmaceuticals that utilize antibodies to deliver toxic chemicals directly to tumors and other dangerous cells while avoiding healthy tissues. This technology is based on the controlled yet spontaneous release of a drug compound via the domino-like cascade effect of the self-immolative spacer system p-aminobenzyl alcohol (PABOH). This report seeks to investigate the effects that various PABOH analogues have on the kinetics of spacer degradation, in an effort to optimize the efficiency of the ADC in a therapeutic context.
Worcester Polytechnic Institute
Major Qualifying Project
All authors have granted to WPI a nonexclusive royalty-free license to distribute copies of the work, subject to other agreements. Copyright is held by the author or authors, with all rights reserved, unless otherwise noted.
Chemistry and Biochemistry