Faculty Advisor

Dittami, James P.

Abstract

Antibody Drug Conjugates (ADCs) represent a rapidly growing and extensively potent class of pharmaceuticals that utilize antibodies to deliver toxic chemicals directly to tumors and other dangerous cells while avoiding healthy tissues. This technology is based on the controlled yet spontaneous release of a drug compound via the domino-like cascade effect of the self-immolative spacer system p-aminobenzyl alcohol (PABOH). This report seeks to investigate the effects that various PABOH analogues have on the kinetics of spacer degradation, in an effort to optimize the efficiency of the ADC in a therapeutic context.

Publisher

Worcester Polytechnic Institute

Date Accepted

January 2014

Major

Chemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Chemistry and Biochemistry

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