Faculty Advisor

Heilman, Destin

Faculty Advisor

Pins, George D.

Faculty Advisor

Rolle, Marsha W.

Abstract

Approximately 35 million cases of significant skin loss require clinical intervention annually. Tissue engineering has shown promise in the development of therapies to regenerate full-thickness skin wounds. Here we present the design of a novel cell-derived extracellular matrix scaffold with antimicrobial properties for dermal wound healing. We optimized decellularization methods, cultured dermal fibroblast sheets, cloned a cathelicidin construct, and expressed cathelicidin in a model cell type as steps toward achieving an antimicrobial dermal scaffold with tailored mechanical strength and bioactivity.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2012

Major

Biomedical Engineering

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Chemistry and Biochemistry

Advisor Department

Biomedical Engineering

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