Pins, George D.
Rolle, Marsha W.
Approximately 35 million cases of significant skin loss require clinical intervention annually. Tissue engineering has shown promise in the development of therapies to regenerate full-thickness skin wounds. Here we present the design of a novel cell-derived extracellular matrix scaffold with antimicrobial properties for dermal wound healing. We optimized decellularization methods, cultured dermal fibroblast sheets, cloned a cathelicidin construct, and expressed cathelicidin in a model cell type as steps toward achieving an antimicrobial dermal scaffold with tailored mechanical strength and bioactivity.
Worcester Polytechnic Institute
Major Qualifying Project
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Chemistry and Biochemistry