Approximately 35 million cases of significant skin loss require clinical intervention annually. Tissue engineering has shown promise in the development of therapies to regenerate full-thickness skin wounds. Here we present the design of a novel cell-derived extracellular matrix scaffold with antimicrobial properties for dermal wound healing. We optimized decellularization methods, cultured dermal fibroblast sheets, cloned a cathelicidin construct, and expressed cathelicidin in a model cell type as steps toward achieving an antimicrobial dermal scaffold with tailored mechanical strength and bioactivity.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Cooper, Jennifer Lee
• Mattessich, Sarah Phyllis
• Prifti Kesseli, Fioleda

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042612-135053

Advisor

• Pins, George D
• Heilman, Destin
• Rolle, Marsha Whitney

Year

• 2012

Date created

• 2012-04-26

Resource type

• Major Qualifying Project

Major

• Interdisciplinary
• Biomedical Engineering

Rights statement

• In Copyright

Last modified

• 2021-02-02