Faculty Advisor

Page, Raymond L.

Abstract

The goal of this project was to design a relatively inexpensive, minimally invasive fixation device for the hind limb of a mouse that uses topical electrical stimulation of skeletal muscle to accurately and repeatedly quantify the force generated by muscle contractions. The device also had to be compatible with surgical procedures visualized using a stereomicroscope. Measurements were acquired following multiple series of electrical stimulation by placement of bipolar electrodes on the tibialis anterior muscle surface. There was no visible evidence of tissue damage at either the knee anchor point or at the point of attachment of ligature to the foot, which was connected to the force transducer. Further, there was no visible damage to the muscle tissue due to electrode placement.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2012

Major

Biomedical Engineering

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biomedical Engineering

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