Faculty Advisor

Weathers, Pamela

Abstract

Artemisinin, a potent antimalarial found in Artemisia annua, is currently used in combination with other antimalarial drugs (ACTs), mainly against Plasmodium parasites. Ingestion of A. annua dried leaves is more efficacious than ACT, possibly due to increased bioavailability of artemisinin. This project used a Caco-2 intestinal model to perform experiments showing the effects of specific phytochemicals on artemisinin transport. Artemisinin transport across Caco-2 monolayers varied with artemisinin concentration.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2015

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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