Rolle, Marsha W.
UMass Medical School
The goal of this project was to establish a noninvasive cancer therapy with minimal side effects, low cost, and specific in targeting tumor cells. The team engineered novel and biocompatible Upconversion Nanoparticles (UCNPs) with a calcium fluoride shell Ytterbium and Erbium core conjugated with a photoactive prodrug 5-Aminolevulinic Acid (ALA-UCNP). UCNPs converted near-infrared light into visible light when excited at ~980nm. Emission of the red light from the ALA-UCNPs activates ALA, causing cell death with exposure to 980nm laser light.
Worcester Polytechnic Institute
Major Qualifying Project
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