Faculty Advisor

Rolle, Marsha W.

Abstract

The goal of this project was to establish a noninvasive cancer therapy with minimal side effects, low cost, and specific in targeting tumor cells. The team engineered novel and biocompatible Upconversion Nanoparticles (UCNPs) with a calcium fluoride shell Ytterbium and Erbium core conjugated with a photoactive prodrug 5-Aminolevulinic Acid (ALA-UCNP). UCNPs converted near-infrared light into visible light when excited at ~980nm. Emission of the red light from the ALA-UCNPs activates ALA, causing cell death with exposure to 980nm laser light.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2014

Major

Biomedical Engineering

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biomedical Engineering

Share

COinS