Faculty Advisor

Ryder, Elizabeth F.

Center

UMMC / University of Massachusetts Medical Center

Abstract

The highly conserved insulin/insulin-like growth factor signaling (IIS) pathway plays a critical role in development, lifespan, and metabolism. In the nematode, Caenorhabditis elegans, there are 40 insulin-like genes. Here, I investigate the transcriptional regulation of one insulin-like gene, ins-27, by knocking down transcription factor expression via RNA interference. I identified sixty five transcription factors as potential regulators of ins-27. By investigating regulators of C. elegans insulin-like genes, we may learn more about the biological processes that modulate insulin expression. This may provide greater insight into the regulation of human insulin-like genes.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2013

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

Share

COinS