Faculty Advisor

Ryder, Elizabeth F.

Center

University of Massachusetts Medical Center

Abstract

The highly conserved insulin/insulin-like growth factor signaling (IIS) pathway plays a critical role in development, lifespan, and metabolism. In the nematode, Caenorhabditis elegans, there are 40 insulin-like genes. Here, I investigate the transcriptional regulation of one insulin-like gene, ins-27, by knocking down transcription factor expression via RNA interference. I identified sixty five transcription factors as potential regulators of ins-27. By investigating regulators of C. elegans insulin-like genes, we may learn more about the biological processes that modulate insulin expression. This may provide greater insight into the regulation of human insulin-like genes.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2013

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

Project Center

University of Massachusetts Medical Center

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