Faculty Advisor

Adams, David S.

Center

University of Massachusetts Medical Center

Abstract

The human gene Suppression of Tumorigenicity-18 (ST-18) encodes a zinc finger protein previously associated with breast carcinoma, however it may have an oncogenic role in the development of Inversion 16 leukemia (inv16). This project assayed the level of ST-18 in inv16 leukemic lines compared to unrelated cancer lines. The data show that ST-18 is more highly expressed in an inv16 acute myeloid leukemic cell line (Me-1) compared to Kasumi-1 and U937 non-inv16 cancer lines. In addition, murine ST-18 was successfully cloned into plasmid vector pMSCV2.2 for use in future over-expression experiments.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2011

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

Project Center

University of Massachusetts Medical Center

Share

COinS