Faculty Advisor

Adams, David S.

Center

UMMC / University of Massachusetts Medical Center

Abstract

The human gene Suppression of Tumorigenicity-18 (ST-18) encodes a zinc finger protein previously associated with breast carcinoma, however it may have an oncogenic role in the development of Inversion 16 leukemia (inv16). This project assayed the level of ST-18 in inv16 leukemic lines compared to unrelated cancer lines. The data show that ST-18 is more highly expressed in an inv16 acute myeloid leukemic cell line (Me-1) compared to Kasumi-1 and U937 non-inv16 cancer lines. In addition, murine ST-18 was successfully cloned into plasmid vector pMSCV2.2 for use in future over-expression experiments.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2011

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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