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Are THP-1 Derived Macrophages a Comparable Model System for Human Dendritic Cells?

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The immune system is integral to human survival, therefore the ability to understand how the system functions is key to advancing medicine. This research aimed to determine if THP-1 derived macrophages would be a comparable model system for human dendritic primary cells. Chromatin immunoprecipitation and LPS time course RNA-Seq experiments were performed to gather epigenetic and transcriptional data from both cell types. A comparative analysis of enhancer landscape and gene expression profiles in both cell types showed that there is a subset of genes in THP-1 derived macrophages that are comparable to the human dendritic primary cells.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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  • E-project-042717-003202
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  • 2017
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  • 2017-04-27
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