University of Massachusetts Medical Center
The importance of the cytosolic receptor, absent in melanoma 2 (AIM2), has recently been discovered. Its influence on inflammatory gene expression is essential for proper inflammatory response. In this study, inflammatory gene expression in wild type macrophages was observed, revealing a key role of AIM2 in certain inflammasome gene expressions. With a combination of the data gathered and additional experimentation, the role of AIM2 in inflammatory gene expression can be appreciated.
Worcester Polytechnic Institute
Major Qualifying Project
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Biology and Biotechnology