Faculty Advisor

Rulfs, Jill

Center

University of Massachusetts Medical Center

Abstract

The importance of the cytosolic receptor, absent in melanoma 2 (AIM2), has recently been discovered. Its influence on inflammatory gene expression is essential for proper inflammatory response. In this study, inflammatory gene expression in wild type macrophages was observed, revealing a key role of AIM2 in certain inflammasome gene expressions. With a combination of the data gathered and additional experimentation, the role of AIM2 in inflammatory gene expression can be appreciated.

Publisher

Worcester Polytechnic Institute

Date Accepted

March 2011

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

Project Center

University of Massachusetts Medical Center

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