Faculty Advisor

Politz, Samuel M

Abstract

The insulin-like growth factor I receptor (IGF-IR) and beta1 integrins promote various cellular events such as migration and proliferation that are important to prostate cancer development. Downregulation of beta1 causes subsequent downregulation of IGF-IR in human prostate cancer LNCaP cells. Expression of IGF-IR was found to be comparable in prostate sections from wild type and prostate specific beta1 conditionally ablated TRAMP mice, a mouse model for prostate cancer. By analyzing the downstream signaling of IGF-IR, the levels of phosphorylated Akt were found to be unaffected by downregulation of beta1 integrins and IGF-IR. This study suggests that beta1 integrins may play a key role in the regulation of IGF-IR expression.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2008

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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