Faculty Advisor

Albrecht, Dirk

Faculty Advisor

Ambady, Sakthikumar

Abstract

The main challenge associated with engineering avascular tissue such as cartilage is overcoming the physiological nutrient perfusion limit of 100 µm. Using a 3D printer, a PLA tissue scaffold with a diameter of 6.2 mm was fabricated. The scaffold was threaded with degradable collagen sutures and filled with a chondrogenic cell line suspended in a 4% alginate hydrogel. The scaffold system successfully supported cell proliferation and differentiation for 1 week, indicating efficient nutrient perfusion to the center of the scaffold.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2015

Major

Biomedical Engineering

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biomedical Engineering

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