The main source of morbidity and mortality in cancer is the metastasis of cancer once it has developed. 4-methylthio-2-oxobutyric acid (MTOB) is a drug shown to be effective in inducing apoptosis in cancer cells regardless of the presence of active p53 tumor suppressor, due to its interaction with CtBP transcription repressor. The purpose of this MQP was to determine whether MTOB is an effective treatment for reducing cancer cell migration. This was done using wound healing assays to characterize cancer cell migration in the presence or absence of MTOB. The results show that the migration of U2OS, HCT116 -/-, and MCF7 cancer cells was reduced by 10 mM MTOB treatment.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Parker, Daniel D

Contributors

• Kovi, Ramesh

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-012510-142052

Advisor

• Adams, David S.

Year

• 2010

Sponsor

• University of Massachusetts Medical School

Date created

• 2010-01-25

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright