Faculty Advisor

Adams, David S.


The main source of morbidity and mortality in cancer is the metastasis of cancer once it has developed. 4-methylthio-2-oxobutyric acid (MTOB) is a drug shown to be effective in inducing apoptosis in cancer cells regardless of the presence of active p53 tumor suppressor, due to its interaction with CtBP transcription repressor. The purpose of this MQP was to determine whether MTOB is an effective treatment for reducing cancer cell migration. This was done using wound healing assays to characterize cancer cell migration in the presence or absence of MTOB. The results show that the migration of U2OS, HCT116 -/-, and MCF7 cancer cells was reduced by 10 mM MTOB treatment.


Worcester Polytechnic Institute

Date Accepted

January 2010


Biology and Biotechnology

Project Type

Major Qualifying Project



Advisor Department

Biology and Biotechnology