Faculty Advisor

Ryder, Elizabeth F

Abstract

The MIG-10 protein has been shown to be involved in cell migration and axon guidance in C. elegans; however, the exact mechanism is still unknown. Previous studies suggest several proteins may interact with MIG-10, including ABI-1, LIN-53, and UNC-53. To further investigate the function of these proteins, viable mutant strains were created and effects on cell migration and process guidance were assessed in vivo. Results suggest that ABI-1, a component of the actin polymerization machinery, and LIN-53, a nucleosome remodeling factor, both have an effect on neuronal cell migration.

Publisher

Worcester Polytechnic Institute

Date Accepted

June 2009

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

Share

COinS