Faculty Advisor

Heilman, Destin

Abstract

The most daunting obstacle in the treatment of Glioblastoma Multiforme (GBM) lies with the impenetrability of the Blood Brain Barrier. This project aimed to design and engineer nanomedicines that have the aptitude to overcome this complication. The method of manufacturing the nanomedicines allowed for a variety of chemotherapeutics to be encapsulated. Once the nanomedicines were proven to be stable, cytotoxicity assays were conducted. GBM specific drugs were not as effective as broad-spectrum chemotherapeutics, even when combined with known pro-apoptotic factors.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2014

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Chemistry and Biochemistry

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