Modeling of cargo transport via molecular motors
PublicDownloadable Content
open in viewerThe motor protein kinesin-1 plays an essential role in transporting cellular cargoes within eukaryotic cells. A group of kinesins ``walking' together can cooperatively transport various cellular cargo over relatively long distances. While much is known about the transport by individual kinesin-1 molecules, very little is known about the specific mechanisms of cooperative kinesin-based transport. Here, we developed a two-dimensional stochastic model of cargo transport via multiple kinesins. The simulation focuses on the modeling of quantum dot cargoes transported along a microtubule. We found that high motor densities lead to increased run lengths, increased association times and decreased velocities, and that our stochastic model recapitulates experimental data reasonably well.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Publisher
- Identifier
- E-project-031413-165336
- Advisor
- Year
- 2013
- Date created
- 2013-03-14
- Resource type
- Major
- Rights statement
Relations
- In Collection:
Items
Items
Thumbnail | Title | Visibility | Embargo Release Date | Actions |
---|---|---|---|---|
AndrewONeill_MQP2013.pdf | Public | Download |
Permanent link to this page: https://digital.wpi.edu/show/6m311q97h