Faculty Advisor

Tuzel, Erkan

Abstract

The motor protein kinesin-1 plays an essential role in transporting cellular cargoes within eukaryotic cells. A group of kinesins ``walking' together can cooperatively transport various cellular cargo over relatively long distances. While much is known about the transport by individual kinesin-1 molecules, very little is known about the specific mechanisms of cooperative kinesin-based transport. Here, we developed a two-dimensional stochastic model of cargo transport via multiple kinesins. The simulation focuses on the modeling of quantum dot cargoes transported along a microtubule. We found that high motor densities lead to increased run lengths, increased association times and decreased velocities, and that our stochastic model recapitulates experimental data reasonably well.

Publisher

Worcester Polytechnic Institute

Date Accepted

March 2013

Major

Physics

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Physics

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