Faculty Advisor

Adams, David S.

Abstract

The NF-kappaB (NF-kB)/Rel family of transcription factors serves an important regulatory role in the production of immune responses and inflammation. The NF-kB family member RelB displays unusual properties in comparison to the other family members, as it exudes inhibitory effects on the pathway along with its traditional function of transcription initiation. Luciferase assays and TNFa ELISAs were used to determine if RelB represses transcriptional activity of NF-kB in a subunit-specific manner, and also to determine if RelB is able to attenuate NF-kB activity in response to HIV-encoded Tat. This in turn would lead to decreased TNFa synthesis. The outcome may have therapeutic potential in the context of neuroAIDS.

Publisher

Worcester Polytechnic Institute

Date Accepted

December 2006

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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