Faculty Advisor

Dittami, James P.

Abstract

A computational method known as the Similarity Ensemble Approach (SEA) was used to predict drug-target interactions for molecular scaffolds previously made in the Dittami lab. Through three different analyses of this SEA data, the most promising scaffolds were determined. These scaffolds will then be synthesized and the predictions will be validated through a biological assay.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2011

Major

Chemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Chemistry and Biochemistry

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