Student Work

Synthesis of New Pharmacophore Scaffolds

Public

Downloadable Content

open in viewer

The photo-initiated cyclization of aryl-vinyl ethers has been shown to create multicyclic natural product-like scaffolds with predicted biological activity. Utilizing this method, one can construct up to three fused rings and six chiral centers in a single experimental operation. A chemo-informatics analysis of these structures has identified scaffolds which are likely to interact with proteins. Using these predictions, our group has constructed two scaffolds with predicted biological activity.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
Creator
Publisher
Identifier
  • E-project-042413-153148
Advisor
Year
  • 2013
Date created
  • 2013-04-24
Resource type
Major
Rights statement

Relations

In Collection:

Items

Items

Permanent link to this page: https://digital.wpi.edu/show/f4752j187