Dittami, James P.
The photo-initiated cyclization of aryl-vinyl ethers has been shown to create multicyclic natural product-like scaffolds with predicted biological activity. Utilizing this method, one can construct up to three fused rings and six chiral centers in a single experimental operation. A chemo-informatics analysis of these structures has identified scaffolds which are likely to interact with proteins. Using these predictions, our group has constructed two scaffolds with predicted biological activity.
Worcester Polytechnic Institute
Major Qualifying Project
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Chemistry and Biochemistry