Faculty Advisor

Olsen, Carissa Lynn

Faculty Advisor

Srinivasan, Jagan

Abstract

The prevalence of Alzheimer’s Disease (AD) is rising worldwide. Characterized by accumulation of amyloid-beta plaques in the brain, AD results in loss of cognitive and motor functions, with a theorized link to metabolism and ATP production. This study used transgenic AD-model and metabolic mutant Caenorhabditis elegans to investigate punicalagin and coenzyme Q10 treatments through behavioral and ATP-quantifying assays. Both treatments were successful in rescuing chemosensation in AD and metabolic mutant strains, suggesting a metabolic deficiency that results in olfactory dysfunction.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2018

Major

Biology and Biotechnology

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Chemistry and Biochemistry

Advisor Department

Biology and Biotechnology

Share

COinS