Faculty Advisor
Olsen, Carissa Lynn
Faculty Advisor
Srinivasan, Jagan
Abstract
The prevalence of Alzheimers Disease (AD) is rising worldwide. Characterized by accumulation of amyloid-beta plaques in the brain, AD results in loss of cognitive and motor functions, with a theorized link to metabolism and ATP production. This study used transgenic AD-model and metabolic mutant Caenorhabditis elegans to investigate punicalagin and coenzyme Q10 treatments through behavioral and ATP-quantifying assays. Both treatments were successful in rescuing chemosensation in AD and metabolic mutant strains, suggesting a metabolic deficiency that results in olfactory dysfunction.
Publisher
Worcester Polytechnic Institute
Date Accepted
April 2018
Major
Biology and Biotechnology
Major
Biochemistry
Project Type
Major Qualifying Project
Copyright Statement
All authors have granted to WPI a nonexclusive royalty-free license to distribute copies of the work, subject to other agreements. Copyright is held by the author or authors, with all rights reserved, unless otherwise noted.
Accessibility
Unrestricted
Advisor Department
Chemistry and Biochemistry
Advisor Department
Biology and Biotechnology