Faculty Advisor

Adams, David S.

Abstract

The primary objective of this study was to determine the effects of CDC-like kinase 1 (CLK1) on differentiation of a telogen skin stem cell line as a follow-up study to Dr. Lyle's previous work on the differentiation of hair follicle cells. CLK1 knockdown strains were created using shRNA, then differentiated via several induction pathways. Cells lacking CLK1 differentiated along the sebocyte differentiation pathway similarly to the controls, but displayed no epidermal differentiation. These results suggest that CLK1 is necessary for epidermal differentiation, but plays no role in the differentiation of sebocytes.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2010

Major

Biology and Biotechnology

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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