The Role of p53 Serine 23 in Insulin Resistance
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open in viewerAtaxia Telangiectasia (A-T) patients exhibit several clinical pathologies, including Type- 2 Diabetes. However, the major factors that contribute to insulin resistance in A-T patients are still unclear. In this project, the mouse model p53Ser23Ala exhibited insulin resistance. The expression of p53-dependent antioxidant genes (Sestrin 1, 2 and 3) in the fibroblasts of the p53Ser23Ala mice was found to be significantly decreased, indicating the potential for increased oxidative stress. As p53 is the key downstream effector in the disrupted ATM-p53 signaling pathway, these data have implicated that p53 Ser23 plays an important role in insulin resistance by regulating the expression of Sestrin genes.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Publisher
- Identifier
- E-project-043014-161013
- Advisor
- Year
- 2014
- Sponsor
- Date created
- 2014-04-30
- Resource type
- Major
- Rights statement
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MQP-Khanh-Final_Version.pdf | Public | Download |
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