University of Massachusetts Medical Center
UMass Medical School
Ataxia Telangiectasia (A-T) patients exhibit several clinical pathologies, including Type- 2 Diabetes. However, the major factors that contribute to insulin resistance in A-T patients are still unclear. In this project, the mouse model p53Ser23Ala exhibited insulin resistance. The expression of p53-dependent antioxidant genes (Sestrin 1, 2 and 3) in the fibroblasts of the p53Ser23Ala mice was found to be significantly decreased, indicating the potential for increased oxidative stress. As p53 is the key downstream effector in the disrupted ATM-p53 signaling pathway, these data have implicated that p53 Ser23 plays an important role in insulin resistance by regulating the expression of Sestrin genes.
Worcester Polytechnic Institute
Major Qualifying Project
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Chemistry and Biochemistry