Faculty Advisor

Adams, David S.

Abstract

The production of monoclonal antibodies (mAbs) is fast becoming a staple of pharmaceutical development. Understanding how differing feeds and bioreactor setups affects the production of mAbs is important for improving yields. In the process of manufacturing mAb IPTG1, an anti- phosphotyrosine antibody produced at Millipore, this project monitored cell viability and secreted antibody yields under a variety of culture conditions, including different media feeds and different gas spargers.

Publisher

Worcester Polytechnic Institute

Date Accepted

May 2014

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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