Faculty Advisor

Adams, David S.

Center

University of Massachusetts Medical Center

Abstract

The proteins Mdm2 and MdmX are critical negative regulators of the tumor suppressor p53 and, when overexpressed, they function as oncogenes. However, recent research has shown MdmX to function as a tumor suppressor in p53-deficient mice and to increase genome stability in p53-deficient mouse cells. This project investigates the effect of MdmX on genomic stability in human breast cancer cells. The results show a correlation between MdmX and a decrease in multipolar spindles, along with an increase in chromosome number. These findings could provide a fundamental understanding of the role of genomic stability in human cancer.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2013

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

Project Center

University of Massachusetts Medical Center

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