The purpose of this MQP is to develop and implement methods to determine where paclitaxel is stored and produced in Taxus cells. This research is significant to the broader goal of paclitaxel production optimization in that research will inform engineering strategies to increase secretion to extracellular media. This MQP can be divided into four parts: cellular fractionation, organelle analysis through assay development, quantification of paclitaxel, and finally the combination of the data to determine paclitaxel localization.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Crowell, Lexi
• LaRoche, Margaret Ann

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-032218-105434

Advisor

• Roberts, Susan Celia

Year

• 2018

Date created

• 2018-03-22

Resource type

• Major Qualifying Project

Major

• Chemical Engineering

Rights statement

• In Copyright