Faculty Advisor

Adams, David S.

Abstract

The purpose of this project was to analyze the function of a newly discovered subtype of CD8+ cell in mice, the T6-alpha subtype. Through assays of in vitro stimulation, cytotoxicity, and secondary memory responses in vivo, we explored the function of the T6-alpha subset of CD8+ T- cells. The data show that in response to an influenza virus infection in mice, the T6-alpha cells produce large quantities of IFN-gamma, lesser amounts of IL-2, and no detectable TNF- alpha and IL17. Future experiments focusing on T6- alpha kinetics and in vivo function could aid in development of future immune treatments.

Publisher

Worcester Polytechnic Institute

Date Accepted

March 2012

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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