Student Work

Perfusion Bioreactor for the Development of Tissue-Engineered Blood Vessels

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The purpose of this project was to design a perfusion bioreactor to nourish the lumen of a tissue tube comprised of rat smooth muscle cells in order to eliminate luminal cell necrosis. Once the bioreactor was deemed suitable for living tissue, a 19-day old tissue tube was mounted inside the bioreactor and the bioreactor ran for 3 days inside an incubator. Control tissue tubes were grown statically on silicone mandrels for 3 days. Tissue tubes preserved on the same day that the bioreactor was put in the incubator also served as control tissues to compare the size and morphology of tissue tube cultured in the bioreactor with tissue tubes harvested prior to incubation. The bioreactor was designed to provide an innovative way to mount tissue tubes to introduce luminal perfusion.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
Creator
Publisher
Identifier
  • E-project-041911-153426
Advisor
Year
  • 2011
Date created
  • 2011-04-19
Resource type
Major
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Last modified
  • 2021-02-02

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