Faculty Advisor

Adams, David S.

Abstract

Avian influenza is a highly mutable RNA virus that is readily passed between bird species, and from birds to humans. It is possibly the greatest airborne pandemic threat to the human population. An inexpensive vaccine that is easy to produce, store, and administer is necessary for the prevention of this disease. We purified a novel protein construct (U65-mHAt) which includes the mature transcript of Influenza A subtype H5N1 virus and loaded it into particles made of beta-glucan, a known adjuvant that has been shown to improve immune system response to the influenza vaccine. This system is cost effective, can be rapidly amplified, and is easily administered making it a viable option for preventing a worldwide H5N1 pandemic.

Publisher

Worcester Polytechnic Institute

Date Accepted

May 2009

Major

Biology and Biotechnology

Major

Humanities and Arts

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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