Arguello, Jose' M.
The Sinorhizobium meliloti genome encodes five Cu+-ATPases that aid in detoxification and regulate copper homeostasis via the efflux of copper from the cytoplasm to the periplasmic space. Bioinformatic analysis concluded that additional cuproproteins found in S. meliloti genome might interact with Cu+-ATPases to aid in copper homeostasis. Atomic Absorption Spectroscopy (AAS) was used to determine the concentration of copper in subcellular fractionation of wild type and mutant strains. Results suggest that copper distribution in different subcellular fractions is linked to the dynamic of copper transporters and cuproproteomes.
Worcester Polytechnic Institute
Major Qualifying Project
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Chemistry and Biochemistry