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Effects of Genistein in Over-the-Counter Phytoestrogen Supplements on Ovarian Cancer Cells

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B-Estradiol hormone replacement therapy (HRT) is used by perimenopausal and postmenopausal women to alleviate menopausal symptoms. HRT can upregulate cell proliferation in estrogen responsive tissues. We focused on using over-the-counter (OTC) phytoestrogen supplements containing genistein as an alternative to HRT. Using ovarian cancer cells OVCAR-3, we exposed the cells to various OTC phytoestrogen supplements, and performed cell proliferation assays to measure the response. We found OTC phytoestrogens had an antiproliferative effect on the OVCAR-3 cells, but found no correlation between the amount of genistein and the strength of the antiproliferative effect of the phytoestrogen. In conclusion, we propose taking phytoestrogen supplements as an alternative to b-Estradiol HRT.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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  • E-project-042717-103956
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  • 2017
Date created
  • 2017-04-27
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