Faculty Advisor

Buckholt, Michael Allan

Faculty Advisor

Rulfs, Jill

Abstract

B-Estradiol hormone replacement therapy (HRT) is used by perimenopausal and postmenopausal women to alleviate menopausal symptoms. HRT can upregulate cell proliferation in estrogen responsive tissues. We focused on using over-the-counter (OTC) phytoestrogen supplements containing genistein as an alternative to HRT. Using ovarian cancer cells OVCAR-3, we exposed the cells to various OTC phytoestrogen supplements, and performed cell proliferation assays to measure the response. We found OTC phytoestrogens had an antiproliferative effect on the OVCAR-3 cells, but found no correlation between the amount of genistein and the strength of the antiproliferative effect of the phytoestrogen. In conclusion, we propose taking phytoestrogen supplements as an alternative to b-Estradiol HRT.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2017

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

Advisor Program

Biology and Biotechnology

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