The successful delivery of vaccine antigens such as peptides and proteins to stimulate CD4 and CD8 T cell immunity could provide a prevention or treatment of infectious diseases and malignant disorders. This project tested different strategies of peptide delivery to phagocytic cells using using Beta-glucan particles (GPs), and assayed the in vitro immune-stimulatory capabilities. GPs are hollow microparticles derived from Baker’s yeast that can be used to encapsulate or bind peptide payloads to ensure delivery to target cells. Various synthetic strategies were evaluated to identify an effective delivery method for in vitro testing using a T-cell proliferation assay.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Negmetzhanov, Baurzhan

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-030912-143652

Advisor

• Adams, David S.

Year

• 2012

Sponsor

• UMass Med

Date created

• 2012-03-09

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright