Faculty Advisor

Adams, David S.

Abstract

The successful delivery of vaccine antigens such as peptides and proteins to stimulate CD4 and CD8 T cell immunity could provide a prevention or treatment of infectious diseases and malignant disorders. This project tested different strategies of peptide delivery to phagocytic cells using using Beta-glucan particles (GPs), and assayed the in vitro immune-stimulatory capabilities. GPs are hollow microparticles derived from Baker’s yeast that can be used to encapsulate or bind peptide payloads to ensure delivery to target cells. Various synthetic strategies were evaluated to identify an effective delivery method for in vitro testing using a T-cell proliferation assay.

Publisher

Worcester Polytechnic Institute

Date Accepted

March 2012

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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