Faculty Advisor

Page, Raymond L.

Abstract

The use of an in vitro skeletal muscle model can transform clinical research such as drug screening for muscular myopathies. Current techniques are not suitable due to the lack of homology between models and native skeletal muscle. The need that this model must address, is a model that accurately mimics native skeletal muscle. Our group developed a modular polycarbonate culture dish with PDMS posts and agarose molds to improve upon cell density and cell self-assembly. The dish has the ability to provide axial stimulation in both the negative and positive direction. The hope is that stimulus will lead to the maturation of tissue into levels of strength and function similar to native muscle. This device can provide a better model that, if confirmed, may lead to a future clinical model.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2014

Major

Biomedical Engineering

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biomedical Engineering

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