Faculty Advisor

Olsen, Carissa Lynn

Center

UMMC / University of Massachusetts Medical Center

Abstract

There are nearly 23,000 described species of nematodes and most thrive within neutral environments. However, some nematodes are able to live under more “extreme” conditions. Turbatrix aceti is able to thrive within an especially acidic environment. Prior research from the Alkema lab suggests that T. aceti survives in part by metabolizing acetic acid taken in by Aquapoirn-7. To analyze the role of AQP-7, I cloned and characterized the gene that encodes an ortholog of AQP-7 found in Caenorhabditis elegans. These studies show that C. elegans aqp-7 is expressed in several tissues and suggest that C. elegans AQP-7 is able to transport acetic acid across the membrane. Due to the similarity, it is likely that T. aceti AQP-7 performs this way as well.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2018

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Chemistry and Biochemistry

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