Faculty Advisor

Pins, George D

Abstract

There is a need for skin substitutes that provide enhanced vascularization and tissue ingrowth to the wound site to maximize skin regeneration and eliminate the need for additional surgeries. The team modified a novel full-thickness skin substitute known as micro-patterned dermal-epidermal regeneration matrix (μDERM) to enhance its ability to promote vascularization in vivo. Heparin and Fibroblast Growth Factor-2 (FGF-2) were incorporated into the dermal component. Migration of fibroblasts in response to these factors was assessed in vitro. While the non-heparinized sponges with a 300 ng/mL concentration of FGF-2 showed greatest outgrowth rates, the study would need to be performed over a longer period of time to understand the maximum potential effects of the heparin on the system.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2014

Major

Biomedical Engineering

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biomedical Engineering

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