Pins, George D
There is a need for skin substitutes that provide enhanced vascularization and tissue ingrowth to the wound site to maximize skin regeneration and eliminate the need for additional surgeries. The team modified a novel full-thickness skin substitute known as micro-patterned dermal-epidermal regeneration matrix (μDERM) to enhance its ability to promote vascularization in vivo. Heparin and Fibroblast Growth Factor-2 (FGF-2) were incorporated into the dermal component. Migration of fibroblasts in response to these factors was assessed in vitro. While the non-heparinized sponges with a 300 ng/mL concentration of FGF-2 showed greatest outgrowth rates, the study would need to be performed over a longer period of time to understand the maximum potential effects of the heparin on the system.
Worcester Polytechnic Institute
Major Qualifying Project
All authors have granted to WPI a nonexclusive royalty-free license to distribute copies of the work, subject to other agreements. Copyright is held by the author or authors, with all rights reserved, unless otherwise noted.
Your accessibility may vary due to other restrictions.