Faculty Advisor

Rulfs, Jill

Faculty Advisor

Shivkumar, Satya

Abstract

There is renewed interest in silks as a biomaterial due to their unique mechanical properties, highly organized structure, and diverse surface chemistry. This study investigates silk's efficacy as an alternative biomaterial for bone regeneration and analyzes the role of adhesion and signaling factors in the process. Femoral defects in rodents were implanted with a series of scaffold combinations. Parameters included scaffold decoration (RGD or BMP-2) and hMSCs. Radiological and DEXA analyses demonstrated that scaffolds with BMP-2 and empty scaffolds produced the most bone ingrowth and defect bridging.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2005

Major

Biology and Biotechnology

Major

Biomedical Engineering

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

Advisor Department

Mechanical Engineering

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