Faculty Advisor

Brodeur, Drew R

Abstract

This Major Qualifying Project investigated blood testing as a noninvasive detection method and evaluation of the risk of Unruptured Intracranial Aneurysms (UIAs). By mimicking hypertension with manipulation of blood pressure and vascular wall repair inhibitors in the rabbit samples, it was hypothesized that there would be an increase in antibodies produced which will readily bind to the AFHYESQ peptide. Our results show a positive correlation between increase in blood pressure and increase in titer, which indicate more presence of bound antibodies, showing a more prevalent immune response to the AT1R. An ELISA assay was used for all serum samples, which can now be expanded to other models for continuous sampling.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2017

Major

Chemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Chemistry and Biochemistry

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