Faculty Advisor

Adams, David S.

Faculty Advisor

Gaudette, Glenn R.

Abstract

Based on promising results seen in regenerative therapies for wound healing, this study explores the use of delivering stem cells through a fibrin hydrogel for the treatment of emphysema. To determine an optimal formulation of the biopolymer fibrin, gene expression of lung resident mesenchymal stem cells (LR-MSCs) was studied in three different scaffold formulations. In addition, mechanical modeling was completed to correlate any uncharacteristic behavior with a change in mechanical properties. The results from the study indicated that 3 mg/mL fibrinogen with 500U thrombin may be optimal; however, additional testing needs to be completed to validate mechanical modeling and demonstrate the potency potential of LR-MSCs on secondary cell lines.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2014

Major

Biology and Biotechnology

Major

Biomedical Engineering

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

Advisor Department

Biomedical Engineering

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