Faculty Advisor

Emmert, Marion H

Abstract

Benzylic amines are key components of biologically significant compounds and can be found in several top-selling prescription drugs. As such, developing facile syntheses for complex, biologically-important compounds is an important issue facing the pharmaceutical industry. While catalysis can typically design “greener” reactions, current catalytic syntheses of benzylic amines utilize hazardous or waste-intensive reagents and often fail to synthesize useful products in one step. Our studies sought to develop Cu-catalyzed systems for benzylic aminations through the use of novel amination reagents. Cu precursors, ligands, and additives have been surveyed to establish efficient reactions that generate benzylic C-N bonds directly from benzylic C-H bonds in a one pot, single step synthesis.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2014

Major

Environmental and Sustainability Studies

Major

Chemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Chemistry and Biochemistry

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