Copper-catalyzed methods for benzylic C-H bond amination

Darcy, Julia Whitney

Student Work

Copper-catalyzed methods for benzylic C-H bond amination

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Benzylic amines are key components of biologically significant compounds and can be found in several top-selling prescription drugs. As such, developing facile syntheses for complex, biologically-important compounds is an important issue facing the pharmaceutical industry. While catalysis can typically design “greener” reactions, current catalytic syntheses of benzylic amines utilize hazardous or waste-intensive reagents and often fail to synthesize useful products in one step. Our studies sought to develop Cu-catalyzed systems for benzylic aminations through the use of novel amination reagents. Cu precursors, ligands, and additives have been surveyed to establish efficient reactions that generate benzylic C-N bonds directly from benzylic C-H bonds in a one pot, single step synthesis.

This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

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