Faculty Advisor

Gibson, Daniel G

Abstract

Binding of antibodies to Acetylcholine receptors (AChR) on skeletal muscle prevents or weakens contraction, as in the human autoimmune disease Myasthenia Gravis (MG), also inducible in rats. The horseshoe crab (Limulus polyphemus), an ancient arthropod, is an unlikely candidate for neuromuscular control by acetylcholine because most arthropods'' muscles are innervated by glutamatergic (excitatory) and GABAergic (inhibitory) neurons. Nevertheless, monoclonal anti-human AChR antibody caused eserine-reversible paralysis in Limulus larvae and juveniles, and in severed legs.

Publisher

Worcester Polytechnic Institute

Date Accepted

May 2007

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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