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HIGHER LEVELS OF ER STRESS PROTEINS OCCUR IN PANCREATIC ISLETS OF DIABETIC PRONE VERSUS RESISTANT RATS

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Bio Breeding (BB) rats are a well known model for juvenile diabetes. Diabetic prone (DP) and resistant (DR) lines were created by in-breeding. DP rats spontaneously develop diabetes via pancreatic beta cell death, but the exact mechanism remains unknown. This project investigated cellular levels of several proteins thought to play a role in endoplasmic reticulum (ER) stress, which could lead to beta cell death. Levels were compared in pancreatic islets from DP and DR thapsigargin-stressed and non-stressed rats by western blot and real-time PCR assays. The results indicated that DP rats manifested higher levels of ER stress proteins.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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  • E-project-042506-194241
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  • 2006
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Date created
  • 2006-04-25
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