Faculty Advisor

Brodeur, Drew R

Center

UMMC / University of Massachusetts Medical Center

Abstract

Biocompatible polymer-coated nanoparticles are at the forefront of research into the ever expanding field of drug delivery. We synthesized a reactive O-imidazolide precursor of methoxy polyethylene glycol (MPEG) and linked it to poly-L-lysine of two separate molecular masses to synthesize biocompatible protected graft copolymers (MPEG-gPLL). MPEG-gPLLs were then used for coating gold nanoparticles obtained in the presence of citrate as a capping/reducing reagent. We also performed the assessment of stabilization using surface plasmon changes and fluorescence spectroscopy and determined the appropriate concentrations of PGC to be between 0.0156 and 0.004 mg/ml and nanoparticles to be 0.99 mg/ml for optimal binding to the surface of the nanoparticles.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2013

Major

Chemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Chemistry and Biochemistry

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