Faculty Advisor

Gaudette, Glenn R

Abstract

Biological microthreads are one method of stem cell delivery. However, during delivery, cells are damaged due to forces from the heart wall. A protective sheath was designed that encompassed the threads to increase the number of cells successfully delivered. The sheath possesses mechanical stability to withstand the forces placed on it during surgery. The team conducted various tests including mechanical strength and threading through the heart wall to determine whether the sheath successfully delivered cell-seeded microthreads to the heart. The team discovered that a protective sheath made from electrospun polyethylene terephthalate provided sufficient mechanical stability to protect cell-loaded microthreads during delivery to the heart.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2010

Major

Biomedical Engineering

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biomedical Engineering

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