Faculty Advisor

Ambady, Sakthikumar

Faculty Advisor

Granquist-Fraser, Domhnull

Abstract

Bone tissue engineering has many potential applications including healing bone after trauma, repairing and bone defects associated with cancer. However tissue scaffolds are required to create 3D cultures in vitro. Current scaffold fabrication techniques do not allow for adequate control over the internal pore network. With the advent of rapid prototyping fully customized pore structures are feasible. Here we describe the process for creating a biomorphic bone tissue engineering Poly-lactide scaffold using a low cost 3D extrusion printer. We have developed a scaffold that is built fully using a 3d printer and successfully seeded with mouse osteoblast cells using a collagen hydrogel. We have determined that this scaffold has biomimetic geometry and preserves cellular bio-functionality.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2013

Major

Biomedical Engineering

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biomedical Engineering

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