Faculty Advisor

Duffy, Joseph B.

Abstract

Breast cancer affects ~1 million new women yearly. Overexpression of ErbB2, a member of the EGFR family, is a causative factor in 30% of these cases and is targeted by the cancer drug Herceptin. Strikingly, studies of ErbB2 and the Drosophila EGFR have uncovered a close structural relationship. Using domain swaps between dEGFR and ErbB2, I have been investigating inhibition of dEGFR by the transmembrane molecule Kekkon1 with the hope that such insight may lead to novel cancer drugs.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2010

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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