Faculty Advisor

Olsen, Carissa Lynn

Faculty Advisor

Srinivasan, Jagan

Abstract

C. elegans is capable of detecting and responding to various odors and pheromones, including several ascarosides- small molecules produced by C. elegans which enable intraspecies communication. Octapamine Succinyl Ascaroside #9 (osas#9) is released by starved L1 C. elegans larvae and induces an olfactory avoidance response. However, due to multisensory integration in response to osas#9 and an unknown metabolite in OP50 E. coli, the avoidance behavior is attenuated in young adults. Avoidance behavior assays and attenuation assays were performed and determined the need for the MOD-1 serotonin gated chloride channel and implicated the possible partial involvement of the serotonin uptake transporter MOD-5 and the neuropeptide receptor NPR-1 in attenuation of the osas#9 avoidance pathway.

Publisher

Worcester Polytechnic Institute

Date Accepted

September 2017

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Chemistry and Biochemistry

Advisor Department

Biology and Biotechnology

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