Cancer affects millions of people worldwide each year. Although effective treatments have been established for many forms of the disease, these therapies target the tumor suppressor p53, which is not involved in all cancers. It is thus critical to seek novel treatment methods that can affect cancers independent of p53. One group of homologous viruses have been found to code for a set of homologous proteins that selectively induce apoptosis in transformed cells in a p53 independent manner. This group includes the human homolog Torque Teno Virus (TTV). In order to explore TTV VP3’s potential as a cancer therapeutic, several experiments concerning localization and multimerization were performed to evaluate and compare the apoptotic pathways of the highly characterized CAV Apoptin and TTV VP3.
Worcester Polytechnic Institute
Major Qualifying Project
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Chemistry and Biochemistry