Faculty Advisor

Heilman, Destin

Faculty Advisor

Rolle, Marsha Whitney

Center

UMMC / University of Massachusetts Medical Center

Abstract

Candida albicans commonly infect medically implanted devices. To combat C. albicans’ increasing resistance to current treatment methods, a preventative measure was developed by incorporating Filastatin into silicone catheters. Filastatin was shown to inhibit the adhesion of cells by constraining the development of hyphae that allow the cells to adhere to one another and to surfaces. Different drug incorporation methods were developed and tested to determine the best way to utilize Filastatin in order to inhibit C. albicans from adhering to silicone urinary catheters.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2016

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Chemistry and Biochemistry

Advisor Department

Biomedical Engineering

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