Rolle, Marsha Whitney
UMMC / University of Massachusetts Medical Center
University of Massachusetts Medical School
Candida albicans commonly infect medically implanted devices. To combat C. albicans’ increasing resistance to current treatment methods, a preventative measure was developed by incorporating Filastatin into silicone catheters. Filastatin was shown to inhibit the adhesion of cells by constraining the development of hyphae that allow the cells to adhere to one another and to surfaces. Different drug incorporation methods were developed and tested to determine the best way to utilize Filastatin in order to inhibit C. albicans from adhering to silicone urinary catheters.
Worcester Polytechnic Institute
Major Qualifying Project
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Chemistry and Biochemistry